cas:1534-35-6
產品名：異寡膽酸。
結構式：
包裝：50mg 100mg 500mg 1g 5g 50g
產品描述：異石膽酸是一種膽汁酸，由石膽酸或3-硫酸石膽酸的微生物代謝形成[1],[2] isolithocholic acid (0.01%) inhibits spore germination induced by taurocholic acid in the c. difficile strains cd196, m68, bi9, and 630, as well as inhibits growth and decreases the cytotoxicity of c. difficile culture supernatants to vero cells when used at a concentration of 0.0003%.[3] fecal levels of isolithocholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.[4]
reference:
1].batta, a.k., salen, g., and shefer, s.transformation of bile acids into iso-bile acids by clostridium perfringes: possible transport of 3β-hydrogen via the coenzymehepatology5(6)1126-1131(1985)
2].borriello, s.p., and owen, r.w.the metabolism of lithocholic acid and lithocholic acid-3-α-sulfate by human fecal bacterialipids17(7)477-482(1982)
3].thanissery, r., winston, j.a., and theriot, c.m.inhibition of spore germination, growth, and toxin activity of clinically relevant c. difficile strains by gut microbiota derived secondary bile acidsanaerobe4586-100(2017)
4].lin, h., an, y., tang, h., et al.alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat modelj. agric. food chem.67(13)3624-3632(2019)
生物活性：異石膽酸（lithocholic acid）是石膽酸的異構體 isolithocholic acid, a bile acid, is formed by microbial metabolism of lithocholic acid or lithocholic acid 3α-sulfate
體外研究：0時異石膽酸01 % does not inhibit spore germination and outgrowth of cf5 and m120, but it significantly inhibits at the higher concentration (0.1 %)isolithocholic acid (0.00003 %)prevents growth of cd196, m68, cf5, 630, and bi9 and significant decreases strains cf5, bi9, m120, and 630 in toxin activity. isolithocholic acid (0.0003 %)makes that all strains displays a significant decrease in toxin activity, except for r20291 and m120
一般提示：請根據產品在不同溶劑中的溶解度選擇合適的溶劑配製儲備溶液; 溶液製備完成後，請將其存放在單獨的包裝中，以避免因反覆凍融迴圈而導致產品故障。
儲存溶液的方式和時間：在 -80°C 下儲存時在 6 個月內使用，在 -20°C 下儲存時在 1 個月內使用。
為了提高溶解度，將試管加熱至37度，然後在超聲波浴**中加熱一段時間。